基本信息

个人情况综述

Pascal Boireau博士：男，1958年6月生，法国人。现任吉林大学人兽共患病研究所客座教授，博士生导师，目前已为我室培养博士生1人（2009年毕业），每年来华来校来我课题组工作3个月。先后任法国食品安全局巴黎总部部长， 国际旋毛虫病委员会执行委员， 欧盟第五框架旋毛虫项目首席科学家， 北京第29届夏季奥运会-食品安全委员会海外专家（5人之一），先后发表旋毛虫研究相关论文50余篇。

学习工作简历

社会学术兼职

现任法国转基因动植专家委员会委员，法国食品安全局寄生虫部及法国国家兽医大学预防医学部部长，第十届（2000）国际旋毛虫病会议主席。

教学工作

主要科研方向

食品安全和人兽共患病方向

主要科研项目

现主持大型课题情况：

1.欧盟第五研究框架（Fifth Framework Program）“Safe pork and horse meat on Eu-markets: early and unbiased diagnostic tests for Trichinella”, 课题编号：TRICHIPORSE-QLRT-2001 -01156，批准日期：2001.12，资助强度：130万欧元，主持人。

2.欧盟第六研究框架最佳科学家网络，“Transcriptome différentiel dans le genre Trichinella en utilisant une puce à ADN du stade parasitaire Adulte-L1 nouveau-nées”，课题编号：TRICHIPORSE-QLRT-2003-03078，批准日期：2003.8，资助强度：600万欧元，主持人。

中法合作经历：

1.国家科技部1997年度“中法先进研究计划”《Cloning and Expression of Gene Coding for immunodominant Antigens of L1NN/Adult Stages of Trichinella with Procaryotic Vector and attenuated Aujeszky virus, Establishing of a Recombinant Vaccine against Trichinella and Aujeszky Disease.Recombinant vaccine of Aujeszky and Trichinella》。课题编号：PRA9612, 批准日期：1997.1，资助强度：100万法郎，主持人。

2.国家科技部2003年度“中法先进研究计划”Clonage et expression de gènes codant pour des antigènes immunodominants des stades L1NN/adulte de Trichinella à l’aide de vecteurs procaryotes et eucaryotes ; mise en place d’un test ELISA précoce chez le porc à l’aide d’antigènes recombinants ”. 课题编号：BT0301, 批准日期：2003.1，资助强度：10万欧元，主持人。

主要科研成果

论文发表情况：

P20 – Xinping Zhu, Garcia Reyna Patricia, Jing Yaping, Chengyao Li, Mingyuan Liu, Ortega Pierres Guadalupe, Boireau Pascal (2003). Molecular cloning and sequen ce analysis of a stage specific ORF from a 3 day-old adult worm of Trichinella spiralis. Parasite (sous presse).

P19 - Liu Mingyuan , Boireau P. (2002). An Urgent Problem to be Solved: Trichinellosis Control in China – History and Present Situation of Human and Animal Infections. Trends In Parasitology. 18, 553-556.

P18 - Edoardo Pozio, Ljiljana Sofronic-Milosavljevic, Maria Angeles Gomez Morales, Pascal Boireau, Karsten N?ckler. (2002) Evaluation of ELISA and Western Blot Analysis using three antigens to detect anti-Trichinella IgG in horses. Veterinary Parasitology, 2002, 108 (2):163-178

P17 – Liu Mingyuan , Zhu X.P., Xu K.C., Lu Q., Boireau P. (2001) Biological and genetic characteristics of two Trichinella isolates in China; comparison with European species. Parasite. 8, S34-38

P16 - Aucouturier J, Deville S, Perret C, Vallée I, Boireau P. (2001) Assessment of efficacy and safety of various adjuvants formulations with a total soluble extract of Trichinella spiralis. Parasite. 8, S126-132

P15 - Patrascu I. V., Gamble R., Sofronic-Milosavljevic L., Radulescu R., Andrei A., Ionescu V., Timoceanu V., Boireau P., Cuperlovic K., Djordjevic M., Murrell D., Noeckler K, Pozio E. (2001). The lateral flow card test : an alternative method for the detection of Trichinella infection in swine. Parasite. 8, S240-242

P14 - Labat ML ., Pouchelet M., Gouhier N., Boireau P., Milhaud G . (2001). Regulation by phagic T-lymphocytes of a (pluripotent?) organ stem cell present in adult human blood. A beneficial exception to self-tolerance. Biomed and Pharmacother. 55, 79-90.

P13 - Boireau P , Vallée I, Roman T , Perret C, Fabien , JF , Liu Mingyuan, Gamble H.R., Gajadhar A (2000) Horse trichinellosis: a low frequency for a high human risk. Vet Parasitol, 93, 309-320.

P12 - Trap C, Boireau P (2000). Les protéases chez les helminthes. Vet. Res. 31. 461-471.

P11 - Labat ML ., Milhaud G ., Pouchelet M., Boireau P. (2000). On the track of a lauman circulating mesenchymat stem cell of neural crest origin. Biomed and Pharmacother. 54, 146-62.

P10 - Vayssier M, F. Le Guerhier, J. F. Fabien, C. Vallet, H. Philippe, G Ortega-Pierres, C. Soulé, C. Perret, Liu Mingyuan, M Vega-Lopez, P Boireau. (1999) Cloning and analysis of a Trichinella britovi gene encoding a cytoplasmic heat shock protein of 72 kDa. Parasitology.119. 81-93.

P9 - Boireau P., Vayssier M., Fabien J.F., Perret C., Calamel M., Soulé C. (1997). Antigenic analysis of L1M of Trichinella T1 and T5 using 40 monoclonal antibodies: characterization of eleven antigenic groups and identification of new species markers. Parasitology. 115, 641-651.

P8 - Boireau P, Fabien JF, Vayssier M., Perret C, Soule C et Vautherot JF (1994). Obtention d'anticorps monoclonaux vis à vis des espèces Trichinella spiralis et Trichinella T5: leur utilisation comme marqueur d'espèces. Vet. Res. 25, 606.

P7 - Boireau P, Laporte J, Saulnier D, Madelaine MF, Vautherot JF. (1993) Identification, expression in E coli and insect cells of the non structural proteins NS2 encoded by mRNA2 of Bovine Coronavirus. Adv. Exp. Med. Biol. 342:69-74.

P6 - Rémond M. , Boireau P. , Lebreton F., 1992. Diagnosis of canine parvovirus disease by nucleic hybridization. Archives of Virology . 127. 257-269.

P5 - Vautherot J.F., Laporte J., Boireau P.(1992) Identification of an immunodominant epitope at the C terminal part of the S2 protein. J. Gen. Virol.,73, 3289-3294.

P4 - Vautherot J.F.,.M.F.Madelaine, Boireau P. Laporte J(1992) Bovine coronavirus peplomer glycoproteins: detailed antigenic analyses of S1, S2 and HE. Journal of General Virology,.73, 1725-1737.

P3 - Boireau P., Crucière C. and Laporte J. , 1990. Nucleotide sequence of the glycoprotein S gene of bovine enteric coronavirus and comparison with the S proteins of two mouse hepatitis virus strains. Journal of General Virology, 71, 487-492.

P2 - Woloszyn N. , Boireau P. and Laporte J. , 1990. Nucleotide sequence of the bovine enteric coronavirus BECV F15 mRNA 5 and mRNA 6 unique regions. Nucleic Acids Research, Vol. 18, N?5, 1303.

P1 - Savoysky E. , Boireau P. , Finance C. and Laporte J. , 1990. Sequence and analysis of BECV F15 matrix protein. Res. Virol., 141, 411-425.

-C. TRAP1, FU BAOQUAN1/2, D. LE RHUN1, LIU MINGYUAN2, T. ROMAND1, C. PERRET1 and P. BOIREAU1. Cloning and analysis of a Trichinella spiralis serine protease gene. Article soumis à Parasitology. En correction

X7 – Dupouy-Camet J, Boireau P., Murrell KD. (2001). Highlights of the tenth International Conference on Trichinellosis: past and future. Parasite. 8, S7-9

X6 - Boireau P., Wu Z., Fabien JF., Xu D., Sestier C., Liu M., Ortega-Pierre G., Takahashi Y. (1998) Stage-specific epitopes of Trichinella spiralis and Trichinella T5. Proceedings of The IX international congress of Parasitology, ICOPAIX, Japan, August 1998, 1021-1025.

X5 - Boireau P, Fabien JF, Le Guerhier F, Vayssier M, Perret C, Soulé C. (1997) Detailed antigenic analysis of Trichinella T5 and T1 using monoclonal antibodies. Trichinellosis. 211-218

X4 - Le Guerhier F, Trap C, Vayssier M, Fabien JF, Perret C, Soulé C, Boireau P. (1997). cDNA cloning of the three antigenic stages of Trichinella britovi: establishing of stage specific probe. Trichinellosis. 287-292.

X3 - Vayssier M, Fabien JF, Goutorbe PJ, Guilpain C, Vallet C, Soulé C, Boireau P.(1997) Cloning, sequencing and expression of a cytoplasmic hsp70 of Trichinella britovi; its antegenicity in experimentally infected rabbit, mice and horses. Trichinellosis. 281-286.

X2 - Perret C, Barrat J, Calamel M, Fabien JF, Boireau P, Soulé C .(1997). Comparative humoral responses in a horse and a fox infected and reinfected with Trichinella. Trichinellosis.307-312.

X1 - Boireau P. , Woloszyn N. , Crucière C. , Savoysky E. and Laporte J. , 1990. Sequence analysis of 8,7 Kb of BECV genome. "Coronaviruses and their diseases", 81-88.

T20- Wu Xiuping, Liu Mingyuan, Lu Qiang, Fu Baoquan, Pascal Boireau. (2003) Cloning and expression of a T314 cDNA of Trichinella spiralis. Chinese Journal of Veterinary Science, 23(2):169-171

T19- Pascal Boireau, Jacques Guillot, Bruno Polack, Isabelle Vallée, René Chermette (2002). Risques parasitaires liés aux aliments d’origine animale. Revue Fran?aise des Laboratoires. 348, 71-89.

T18- Liu Mingyuan, Fu Baoquan, Wu Xiuping, Lu Qiang, Yao Chunyu, Pascal Boireau. (2002) Cloning and analysis of a newborn larvae stage-specific cDNA of Trichinella spiralis. Chinese Journal of Veterinary Science, 22(1):37-40

T17- Niu Tingxian, Liu Mingyuan, Fu Baoquan, Wu Xiuping, Zheng Mingguang, Pascal Boireau. (2002) Highly Efficient Expression of Trichinella spiralis Newborn Larva Stage-specific Gene of G10-7 in E．coli. Chinese Journal of Veterinary Science, 22(5):481-483

T16- Fu Baoquan, Liu Mingyuan, Wang Feng, Lu Qiang, Wu Xiuping, Pascal Boireau. (2001) Cloning and Identification of Stage Specific cDNA Fragment of 5 Days Old Adult worm of Trichinella spiralis. Chinese Journal of Veterinary Science and Technology, 31(11):9-11

T15-Meng Xueping, Fu Baoquan, Lu Qiang, Wu Xiuping, Liu Mingyuan, Pascal Boireau. (2001) Cloning and expression of a cDNA encoding a protein with FYVE zinc finger domain of Trichinella Spiralis. Chinese Journal of Veterinary Science and Technology, 31(12):9-12

T14- Boireau P., Liu Mingyuan, Niborski V., Roman T., Vallée I. (2001). Outils de la biologie moléculaire appliqués à l’épidémiologie des trichinelloses animales. Journal AEEMA.39, 75-84.

T13- Liu Mingyuan, Li Chengyao, Wu Xiuping, Fabien Jean Fran?ois, Fu Baoquan, Trap Catherine, Zhang Xichen, Boireau Pascal. (2001). Establishment and primary screening of subtractive cDNA library of Trichinella spiralis. Chinese journal of veterinary science. 21, 4, 355-358.

T12- Liu Mingyuan, Fu Baoquan, Lu Qiang, Wu Xiuping, Yao Chunyu, Yu Li, Dou Lanqing, Boireau Pascal. (2001).Construction of cDNA library of newborn larvae of Trichinella spiralis. Chinese journal of veterinary science and technology. 31, 3. 5-7.

T11- Boireau P et Vallée I. (2001). Les trichinelloses animales : épidémiologie et conséquences pour le contr?le des viandes. Journal d’épidémiologie de l’AFSSA , 1. 2-3.

T10- Boireau P., Perret C., Fabien J.F. (1999) La trichinellose: une zoonose parasitaire persistante. Journal de l’académie vétérinaire.72, 105-114.

T9- Touratier l, Boireau P, Dupouy-Camet J, Pages JP. (1999). La trichinellose du cheval et son importance en santé publique vétérinaire. Faits et conséquence. Bull.Soc.Vet.Prat. T83, 4. 223-264.

T8- Boireau P (1998) Evaluation des risques générés par un OGM. HS Viandes et produits carnés. 1-2 Octobre 1998. 8p.

T7 -Liu Mingyuan, Xu Kecheng, Song Mingxin, P Boireau, JF Fabien, C Soulé. (1998). Species identification of Trichinella isolate SW of Chinese cat. Chinese Journal of Veterinary Science and Technology. 28, 7. 8-9.

T6 -Liu Mingyuan, Xu Kecheng, Song Mingxin, P Boireau, JF Fabien, C Trap, M Vayssier, C Vallet, C Soulé. (1998). Establishing and screening the cDNA libraries of Adult and New born larvae of Chinese Trichinella isolates. Chinese Journal of Veterinary Science. 18, 2. 147-150.

T5-Dupouy-Camet J, Ancelle T, Fourestié V, Boireau P, Soulé C. (1998). Trichinelloses. Encycl. Méd Chir (Elsevier Paris) Maladies infectieuses, 8-517-A-10, 11p.

T4- Moutou F, Boireau P. (1997). Biotechnologies, de quoi s'agit-il?, Journal des Mines. Avril. 11-15.

T3- Boireau P. 1988. Recommandation concernant la préparation et certains aspects du contr?le des produits biologiques à usage vétérinaire. Considérations sur la préparation et le contr?le des medicaments vétérinaires issus de la biotechnologie. Bull.Lab.Vet., 29/30. 4-20p.

获奖信息