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王 琳

作者:时间:2025-03-05点击数:

姓名:

 


性别:

职称:

教授

硕导/博导:

博导

最高学位:

博士

最高学历:

研究生

办公电话:

0431-86985385

邮箱:

wanglin1020@jlu.edu.cn



详细情况

学科专业:

兽医药理学

研究方向:

细菌感染疾病药物靶标发现、新药筛选及相关剂型研究;新兽药开发及检测分析

讲授课程:

药理学,兽药制剂学,药剂学,兽医药理学与毒理学,分子药理学

教育经历:

2003.08-2007.06,沈阳药科大学,药物制剂,学士学位

2007.08-2012.06,中国人民解放军第二军医大学,药理学,博士学位

工作经历:

2012.12-2016.09,吉林大学,人兽共患病研究所,讲师

2016.09-2022.09,吉林大学,人兽共患病研究所,副教授

2022.09-至今,吉林大学,人兽共患病研究所,教授

科研项目:

1. 横向课题,多穗石柯提取物口服液的新兽药研制,3R12058742062020/10-2025/10150.00万元,在研,负责人。

2. 横向课题,金霉素预混剂羊病原菌药敏试验和最佳适应症筛选,3R22200642062021/12-2022/0335.00万元,已结题,负责人。

3. 吉林大学优秀青年教师培养计划, 2018/01-2021/1218

4. 国家自然科学基金青年基金项目,No. 31502117,槲皮素对金黄色葡萄球菌凝固酶的抑制作用及机制,2016/01-2018/1220万,已结题,负责人。

5. 中国博士后科学基金特别资助,2015T80309,金黄色葡萄球菌分选酶SortaseB 抑制剂筛选及机制研究,2015/05-2016/1015万元,已结题,负责人。

6. 中国博士后面上资助,2014M561301,咖啡酸对金葡菌分选酶SortaseA的抑制作用及机制,2014/09-2016/105万元,已结题,负责人。

7. 吉林省科技发展计划科技创新人才培育计划优秀青年人才基金项目,20180520043JH,绵马贯众素通过抑制vWbp蛋白治疗金葡菌感染的药效学评价及机制研究,2018/01-2019/1210万,已结题,负责人。

学术论文:

1. Shi L, Tianqi F, Zhang C, Deng X,   Zhou Y, Wang J*, Wang L*. High-protein compound yogurt with quinoa   improved clinical features and metabolism of high-fat diet-induced   nonalcoholic fatty liver disease in mice. J Dairy Sci. 2023. 106(8):5309-5327.

2. Liu M#, Lv Q#, Xu J, Liu B, Zhou Y,   Zhang S, Shen X*, Wang L*. Isoflavone glucoside genistin, an inhibitor   targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria   monocytogenes in vivo and in vitro. Biochem Pharmacol. 2023. 209:115447.

3. Guan S#, Zhong L#, Yu H, Wang L,   Jin Y, Liu J, Xiang H, Yu H*, Wang L*, Wang D*. Molecular docking and   proteomics reveals the synergistic antibacterial mechanism of theaflavin with   β-lactam antibiotics against MRSA. Front Microbiol. 2022. 13:993430.

4. Guan S#, Yu H#, Xiang H, Wang L,   Liu J, Wu A, Zheng J, Dong H*, Wang L*,Wang D*. WYBQ-4: a New Bactericidal   Agent against Methicillin-Resistant Staphylococcus aureus. Microbiol Spectr.   2022. 10(5):e0054722.

5. Li S, Xu X, Wei L, Wang L*,   Lv Q*. Acacetin Alleviates Listeria monocytogenes Virulence Both In Vitro and   In Vivo via the Inhibition of Listeriolysin O. Foodborne Pathog Dis. 2022. 19(2):115-125.

6. Jin Y#, Yang P#, Wang L#, Gao Z, Lv   J, Cui Z, Wang T, Wang D*, Wang L*. Galangin as a direct inhibitor of   vWbp protects mice from Staphylococcus aureus-induced pneumonia. J Cell Mol   Med. 2022. 26(3):828-839.

7. Wang L#, Li Q#, Li J, Jing S, Jin   Y, Yang L, Yu H, Wang D, Wang T, Wang L*. Eriodictyol as a Potential   Candidate Inhibitor of Sortase A Protects Mice From Methicillin-Resistant   Staphylococcus aureus-Induced Pneumonia. Front Microbiol. 2021. 12:635710.

8. Wang L, Li B, Si X, Liu X, Deng X, Niu X,   Jin Y, Wang D, Wang J. Quercetin protects rats from   catheterrelated Staphylococcus aureus   infections by inhibiting coagulase activity. J Cell Mol Med. 2019.

9. Mu D#, Luan Y#, Wang L#, Gao   Z, Yang P, Jing S, Wang Y, Xiang H, Wang T*, Wang D*. The combination of   salvianolic acid A with latamoxef completely protects mice against lethal   pneumonia caused by methicillin-resistant Staphylococcus aureus. Emerg   Microbes Infect. 2020. 9(1):169-179.

10. Li B, Jin Y, Xiang H, Mu D, Yang P,   Li X, Zhong L, Cao J, Xu D, Gong Q, Wang T, Wang L*,   Wang D*. An Inhibitory effect of Dryocrassin ABBA on Staphylococcus aureus   vWbp that Protects Mice from Pneumonia. Front Microbiol. 2019. 10:7.

11. Zhong X#, Xiang H#, Wang T#, Zhong   L, Ming D, Nie L, Cao F, Li B, Cao J, Mu D, Ruan K, Wang L*, Wang D*.   A novel inhibitor of the new antibiotic resistance protein OptrA. Chem Biol   Drug Des. 2018 . 92(2):1458-67.

12. Ming D#, Wang D#, Cao F, Xiang H,   Mu D, Cao J, Li B, Zhong L, Dong X, Zhong X, Wang L*, Wang T*.   Kaempferol Inhibits the Primary Attachment Phase of Biofilm Formation in   Staphylococcus aureus. Front Microbiol. 2017. 8:2263.

13. Zhao X, Liu B, Liu S, Wang L*,   Wang J*. Anticytotoxin Effects of Amentoflavone to Pneumolysin. Biol Pharm   Bull. 2017. 40(1):61-7.

14. Bi C, Dong X, Zhong X, Cai H, Wang   D*, Wang L*. Acacetin Protects Mice from Staphylococcus aureus   Bloodstream Infection by Inhibiting the Activity of Sortase A. Molecules.   2016. 21(10).

15. Bi C#, Wang L#, Niu X, Cai   H, Zhong X, Deng X, Wang T*, Wang D*. The use of chlorogenic acid and its   analogues as inhibitors: an investigation of the inhibition of sortase A of   Staphylococcus aureus using molecular docking and dynamic simulation.   Biotechnol Lett. 2016. 38(8):1341-7.

16. Wang L#, Bi C#, Cai H, Liu B, Zhong X,   Deng X, Wang T, Xiang H, Niu X*, Wang D*. The therapeutic effect of   chlorogenic acid against Staphylococcus aureus infection through sortase A   inhibition. Front Microbiol. 2015. 6:1031.

17. Wang L#, Bi C#, Wang T, Xiang H, Chen F,   Hu J, Liu B, Cai H, Zhong X, Deng X, Wang D*. A coagulase-negative and   non-haemolytic strain of Staphylococcus aureus for investigating the roles of   SrtA in a murine model of bloodstream infection. Pathog Dis. 2015   Aug;73(6):ftv042.

著作教材:

1. 《分子生物学实验原理与技术》,科学出版社,2015,副主编。

2. 《人兽共患病学》,科学出版社,2015,参编。

获奖情况:

2017吉林大学优秀青年教师培养计划

20142016年青年教师讲课比赛动物医学学院三等奖,2019年一等奖

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