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刘明远

作者:时间:2025-03-05点击数:

姓名:刘明远

 

刘明远-new

性别:男

 

职称:教授

 

硕导/博导:博导

 

最高学位:博士

 

最高学历:研究生

 

办公电话:87836701

 

邮箱:liumy36@163.com

 

 

 

详细情况

学科专业:

预防兽医学

研究方向:

食源性人兽共患寄生虫病

讲授课程:

本科生:兽医公共卫生学

硕士生:人兽共患病研究进展 、兽医公共卫生学、高级兽医公共卫生学、食品卫生与安全研究进展

教育经历:

1981.09-1986.08:   解放军兽医大学兽医学专业         学士

1986.09-1989.08:   解放军兽医大学预防兽医学专业     硕士

1981.09-1986.08:   法国巴黎十二大预防医学专业       博士

工作经历:

2017.02-    今:吉林大学动物医学学院,                                           院长

2016.03-    :   吉林大学人兽共病研究教育部重点实验室,             主任

2014.06-    :   吉林大学OIE亚太区食源性寄生虫病协作中心         负责人

2009.09.07-    :   吉林大学人兽共患病研究所,                                 所长

2004.07-2009.10:   吉林大学人兽共患病研究所(筹),                         教授

1989.07-2004.06:   解放军军需大学畜牧兽医学院,                                 讲师、副教授、教授

科研项目:

1)科技部国家重点研发计划,项目,2017YFD0501300,畜禽重要人兽共患寄生虫病源头防控与阻断技术研究,2017-072020-121928(国拨1768)万元,主持(项目首席科学家)。

2)国家自然科学基金委员会,重点国际(地区)合作研究项目,NSFC31520103916,旋毛虫免疫抑制关键蛋白分子的分离、鉴定及其作用机制探究,2016.01-2020.12249万元,结题,主持。

3)国家自然科学基金委员会,重点项目,NSFC31030064,我国重要食源性人兽共患旋毛虫病的病原侵袭与逃避机制研究,2011.01-2014.12212万元,结题,主持。

4)中央军委科技委,项目,19-163-00-KX-003-002-01,应急治疗用马抗2019-nCoV血清的快速制备,   2020.03-2020.1280万元,结题,主持。

4)广东省海外创新团队项目,横向企业开发项目(深圳市易瑞生物技术有限公司):食源性寄生虫病的诊断抗原抗体研制,2014ZT05S1232016-2019200万元,项目负责人。

5)国家自然科学基金重点项目,我国重要食源性人兽共患旋毛虫病的病原侵袭与逃避机制研究,NSFC310300642011-2014212万元,项目负责人。

6)国家杰出青年基金,旋毛虫与宿主间互作机制研究,NSFC308250332009-2012200万元,主持。

7)科技部863重点项目课题,农村高发及危害严重的人兽共患病病种预防性疫苗的开发与研制,2011AA10A2152011-2013100万元,主持。

8)科技部传染病重大专项项目课题,旋毛虫与华支睾吸虫免疫标识性抗原的筛选及其应用研究,2008ZX10004-112008-2010117万元,主持。

9)科技部863目标导向项目,高质量基因重组蛋白在人兽共患旋毛虫病诊断与检验中的应用,2006AA02Z4512006-2009180万元,主持。

学术论文:

1)                    Liu X, Liu Y, Jin X, He Z, Huang Z, Sun   S, Gao Y, Li J, Ning Q, Xie Z, Jin N, Liu M. Rapidly developable   therapeutic-grade equine immunoglobulin against the SARS-CoV-2 infection in   rhesus macaques. Signal Transduct Target Ther. 2022 Jul 7;7(1):219. doi:   10.1038/s41392-022-01095-8. PMID: 35798694.

2)                    Wang A, Liu X, Heckmann A, Caignard G,   Vitour D, Hirchaud E, Liu M, Boireau P, Karadjian G, Vallée   I. A Trichinella spiralis new born larvae-specific protein, Ts-NBL1,   interacts with host's cell vimentin. Parasitol Res. 2022 Mar 23.

3)                    Jin X, Liu Y, Wang J, Wang X, Tang B,   Liu M, Liu X. β-Glucan-triggered   Akkermansia muciniphila expansion facilitates the expulsion of intestinal   helminth via TLR2 in mice. Carbohydr Polym. 2022 Jan 1;275:118719. doi:   10.1016/j.carbpol.2021.118719. 10.723

4)                    Shi W, Xu N, Wang X, Vallée   I, Liu M, Liu X. Helminth Therapy for Immune-Mediated Inflammatory Diseases:   Current and Future Perspectives. J Inflamm Res. 2022 Jan 21;15:475-491. doi:   10.2147/JIR.S348079.

5)                    Ding J, Tang B, Liu X, Bai X, Wang Y, Li   S, Li J, Liu M, Wang X. Excretory- secretory product of Trichinella spiralis   inhibits tumor cell growth by regulating the immune response and inducing   apoptosis. Acta Trop. 2022 Jan;225:106172. doi:   10.1016/j.actatropica.2021.106172.

6)                    Liu Y, Dong Z, Pang J, Liu M, Jin X.   Prevalence of meat-transmitted Taenia and Trichinella parasites in the Far   East countries. Parasitol Res. 2021 Dec;120(12):4145-4151. doi:   10.1007/s00436-021-07124-9.

7)                    Hu X, Liu X, Li C, Zhang Y, Li C, Li Y,   Chen Y, Guo H, Bai X, Liu M. Time-resolved transcriptional profiling of   Trichinella-infected murine myocytes helps to elucidate host-pathogen   interactions in the muscle stage. Parasit Vectors. 2021 Mar 1;14(1):130. doi:   10.1186/s13071-021-04624-6.

8)                    Wang N, Bai X, Jin X, Tang B, Yang Y,   Sun Q, Li S, Wang C, Chang Q, Liu M, Liu X. The dynamics of select cellular   responses and cytokine expression profiles in mice infected with juvenile   Clonorchis sinensis. Acta Trop. 2021 May;217:105852. doi:   10.1016/j.actatropica.2021.105852.

9)                    Gao X, Yang Y, Liu X, Wang Y, Yang Y,   Boireau P, Liu M, Bai X. Extracellular vesicles derived from Trichinella   spiralis prevent colitis by inhibiting M1 macrophage polarization. Acta Trop.   2021 Jan;213:105761. doi: 10.1016/j.actatropica.2020.105761.

10)                Xu D, Bai X, Xu J, Wang X, Dong Z, Shi   W, Xu F, Li Y, Liu M, Liu X. The immune protection induced by a serine   protease from the Trichinella spiralis adult against Trichinella spiralis   infection in pigs. PLoS Negl Trop Dis. 2021 May 10;15(5):e0009408. doi:   10.1371/journal.pntd.0009408.

11)                Wang Y, Bai X, Tang B, Zhang Y, Zhang L,   Cai X, Lin J, Jia W, Boireau P, Liu M, Liu X. Comparative analysis of   excretory-secretory products of muscle larvae of three isolates of   Trichinella pseudospiralis by the iTRAQ method. Vet Parasitol. 2021   Sep;297:109119. doi: 10.1016/j.vetpar.2020.109119.

12)                Liu X, Feng Y, Bai X, Wang X, Qin R,   Tang B, Yu X, Yang Y, Liu M, Gao F. Comparative multi-omics analyses reveal   differential expression of key genes relevant for parasitism between   non-encapsulated and encapsulated Trichinella. Commun Biol. 2021 Jan   29;4(1):134. doi: 10.1038/s42003-021-01650-z.    6.548

13)                Jin X, Bai X, Zhao Y, Dong Z, Pang J,   Liu M, Liu X. Nrf2 Participates in M2 Polarization by Trichinella spiralis to   Alleviate TNBS-Induced Colitis in Mice. Front Immunol. 2021 Jun 23;12:698494.   doi: 10.3389/fimmu.2021.698494. 8.786

14)                Feng Y, Liu X, Liu Y, Tang B, Bai X, Li   C, Wang X, Deng Y, Gao F, Liu M. Comparative Epigenomics Reveals Host   Diversity of the Trichinella Epigenomes and Their Effects on Differential   Parasitism. Front Cell Dev Biol. 2021 Jun 11;9:681839. doi: 10.3389/fcell.2021.681839.  

15)                Wang X, Tang B, Zhao Y, Ding J, Wang N,   Liu Y, Dong Z, Sun X, Xu Q, Liu M, Liu X. Development of a rapid and   sensitive immunochromatographic strip based on EuNPs-ES fluorescent probe for   the detection of early Trichinella spiralis-specific IgG antibody in pigs.   Vet Res. 2021 Jun 11;52(1):85. doi:10.1186/s13567-021-00951-9.

16)                Hu X, Liu X, Bai X, Yang L, Ding J, Jin   X, Li C, Zhang Y, Li Y, Yang Y, Liu M. Effects of Trichinella spiralis and   its excretory/secretory products on autophagy of host muscle cells in vivo   and in vitro. PLoS Negl Trop Dis. 2021 Feb 18;15(2):e0009040. doi:   10.1371/journal.pntd.0009040.

17)                Liu Y, Liu X, Li Y, Xu N, Yang Y, Liu M,   Zhou Y. Evaluation of a cystatin-like protein of Trichinella spiralis for   serodiagnosis and identification of immunodominant epitopes using monoclonal   antibodies. Vet Parasitol. 2021 Sep;297:109127. doi:   10.1016/j.vetpar.2020.109127.

18)                Jin X, Yang Y, Ding J, Liu X, Shi H, Luo   X, Jia W, Cai X, Vallee I, Boireau P, Bai X, Liu M. Nod-like receptor pyrin   domain containing 3 plays a key role in the development of Th2 cell-mediated   host defenses against Trichinella spiralis infection. Vet Parasitol. 2021   Sep;297:109159. doi: 10.1016/j.vetpar.2020.109159.

19)                Li C, Bai X, Liu X, Zhang Y, Liu L,   Zhang L, Xu F, Yang Y, Liu M. Disruption of Epithelial Barrier of Caco-2 Cell   Monolayers by Excretory Secretory Products of Trichinella spiralis Might Be   Related to Serine Protease. Front Microbiol. 2021 Mar 17;12:634185. doi:   10.3389/fmicb.2021.634185.

20)                Wang N, Bai X, Ding J, Lin J, Zhu H, Luo   X, Fu Z, Zhu C, Jia H, Liu M, Liu X. Trichinella infectivity and antibody   response in experimentally infected pigs. Vet Parasitol. 2021 Sep;297:109111.   doi: 10.1016/j.vetpar.2020.109111.

21)                Zhang D, Qi Y, Cui Y, Song W, Wang X,   Liu M, Cai X, Luo X, Liu X, Sun S. Rapid Detection of Cysticercus cellulosae   by an Up-Converting Phosphor Technology-Based Lateral-Flow Assay. Front Cell   Infect Microbiol. 2021 Nov 10;11:762472. doi: 10.3389/fcimb.2021.762472.   PMID: 34858877; PMCID: PMC8631268.

22)                Liu Y, Xu N, Li Y, Tang B, Yang H, Gao   W, Liu M, Liu X, Zhou Y. Recombinant cystatin-like protein-based competition   ELISA for Trichinella spiralis antibody test in multihost sera. PLoS Negl   Trop Dis. 2021 Aug 25;15(8):e0009723. doi: 10.1371/journal.pntd.0009723. PMID:   34432796; PMCID: PMC8423253.

23)                Li Y, Zhang H, Liu M, Guo W, Yu L.   Microglia NLRP3 Inflammasomes Activation Involving Diabetic Neuroinflammation   in Diabetic Mice and BV2 Cells. Curr Pharm Des. 2021;27(24):2802-2816. doi:   10.2174/1381612827666210716104606. PMID: 34279193.

24)                Xu N, Liu Y, Li Y, Tang B, Liang X, Yang   Y, Liu M, Liu X, Zhou Y. Rapid Quantum Dot Nanobead-mAb Probe-Based   Immunochromatographic Assay for Antibody Monitoring of Trichinella spiralis   Infection. Int J Nanomedicine. 2021 Mar 29;16:2477-2486. doi:   10.2147/IJN.S304845. PMID: 33824586; PMCID: PMC8018372.

25)                Li J, Ding J, Liu XL, Tang B, Bai X,   Wang Y, Qiao WD, Liu MY, Wang XL. Upconverting phosphor technology-based   lateral flow assay for the rapid and sensitive detection of anti-Trichinella   spiralis IgG antibodies in pig serum. Parasit Vectors. 2021 Sep 22;14(1):487.   doi: 10.1186/s13071-021-04949-2. PMID: 34551787; PMCID: PMC8456594.

26)                Wang X, Song W, Ji G, Song Y, Liu X, Luo   X, Liu M, Sun S. Regulation of DNA methylation on key parasitism genes of   Cysticercus cellulosae revealed by integrative epigenomic-transcriptomic   analyses. Hereditas. 2021 Aug 12;158(1):28. doi: 10.1186/s41065-021-00195-9.   PMID: 34384501; PMCID: PMC8361615.

27)                Li Y, Long W, Gao M, Jiao F, Chen Z, Liu   M, Yu L. TREM2 Regulates High Glucose-Induced Microglial Inflammation via the   NLRP3 Signaling Pathway. Brain Sci. 2021 Jul 7;11(7):896. doi:   10.3390/brainsci11070896. PMID: 34356130; PMCID: PMC8306970.

28)                Xu N, Bai X, Liu Y, Yang Y, Tang B, Shi   HN, Vallee I, Boireau P, Liu X, Liu M. The Anti-Inflammatory Immune Response   in Early Trichinella spiralis Intestinal Infection Depends on Serine Protease   Inhibitor-Mediated Alternative Activation of Macrophages. J Immunol. 2021 Mar   1;206(5):963-977. doi: 10.4049/jimmunol.2000290. Epub 2021 Jan 25. PMID:   33495238; PMCID: PMC7887736.

29)                Wang N, Bai X, Ding J, Lin J, Zhu H, Luo   X, Fu Z, Zhu C, Jia H, Liu M, Liu X. Trichinella infectivity and antibody   response in experimentally infected pigs. Vet Parasitol. 2020 Apr 18:109111.   doi: 10.1016/j.vetpar.2020.109111.

30)                Jin X, Bai X, Yang Y, Ding J, Shi H, Fu   B, Boireau P, Liu M, Liu X. NLRP3 played a role in Trichinella   spiralis-triggered Th2 and regulatory T cells response. Vet Res. 2020 Aug   27;51(1):107. doi: 10.1186/s13567-020-00829-2.

31)                Li TT, Tang B, Bai X, Wang XL, Luo XN,   Yan HB, Zhu HF, Jia H, Liu XL, Liu MY. Development of genome-wide polymorphic   microsatellite markers for Trichinella spiralis. Parasit Vectors. 2020 Feb   11;13(1):58. doi: 10.1186/s13071-020-3929-2.

32)                Yang Y, Liu L, Liu X, Zhang Y, Shi H,   Jia W, Zhu H, Jia H, Liu M, Bai X. Extracellular Vesicles Derived From   Trichinella spiralis Muscle Larvae Ameliorate TNBS-Induced Colitis in Mice.   Front Immunol. 2020 Jun 11;11:1174. doi: 10.3389/fimmu.2020.01174.

33)                Xu D, Tang B, Yang Y, Cai X, Jia W, Luo   X, Yan H, Zhang Z, Lin J, Liu M, Liu X. Vaccination with a DNase II   recombinant protein against Trichinella spiralis infection in pigs. Vet   Parasitol. 2020 Mar 5:109069. doi: 10.1016/j.vetpar.2020.109069.

34)                Wang N, Bai X, Tang B, Yang Y, Wang X,   Zhu H, Luo X, Yan H, Jia H, Liu M, Liu X. Primary characterization of the   immune response in pigs infected with Trichinella spiralis. Vet Res. 2020 Feb   21;51(1):17. doi: 10.1186/s13567-020-0741-0.

35)                Jin X, Liu X, Ding J, Zhang L, Yang Y,   Wang X, Yang Y, Liu M. Lentinan improved the efficacy of vaccine against   Trichinella spiralis in an NLRP3 dependent manner. PLoS Negl Trop Dis. 2020   Sep 25;14(9):e0008632. doi: 10.1371/journal.pntd.0008632.

36)                Wang Y, Bai X, Tang B, Zhang Y, Zhang L,   Cai X, Lin J, Jia W, Boireau P, Liu M, Liu X. Comparative analysis of   excretory-secretory products of muscle larvae of three isolates of   Trichinella pseudospiralis by the iTRAQ method. Vet Parasitol. 2020 Apr 22:109119.   doi: 10.1016/j.vetpar.2020.109119.

37)                Jin X, Yang Y, Ding J, Liu X, Shi H, Luo   X, Jia W, Cai X, Vallee I, Boireau P, Bai X, Liu M. Nod-like receptor pyrin   domain containing 3 plays a key role in the development of Th2 cell-mediated   host defenses against Trichinella spiralis infection. Vet Parasitol. 2020 Jun   1:109159. doi: 10.1016/j.vetpar.2020.109159.

38)                Pang J, Ding J, Zhang L, Zhang Y, Yang   Y, Bai X, Liu X, Jin X, Guo H, Yang Y, Liu M. Effect of recombinant serine   protease from adult stage of Trichinella spiralis on TNBS-induced   experimental colitis in mice. Int Immunopharmacol. 2020 Sep;86:106699. doi:   10.1016/j.intimp.2020.106699.

著作教材:

兽医公共卫生学        柳增善、刘明远(主编)                     科学出版社             2016.06

人兽共患病学               柳增善、卢世英、崔树森、刘明远(副主编)            科学出版社    2014.11

获奖情况:

吉林省科学技术发明一等奖    2

军队科学技术进步二等奖       4  

军队科学技术进步三等奖        2

201911月:吉林省创新拔尖人才第一层次;

201608月:国家“万人”人才计划入选者;

201003月:国务院政府特殊津贴;

200901月:国家杰出青年基金;

200609月:国家百千万人才工程国家级人选;

200406月:中国青年科技奖;

200401月:国家杰出青年基金B-海外青年学者合作研究基金依托人;

200301月:吉林省杰出青年基金;

200212月:军队科技新星;

200101月:军队杰出青年基金;

200012月:吉林省青年科技奖。

社会兼职:

2014-至今:   世界寄生虫学者联合会(WFP,执行委员会委员;

2007-2019:   国际旋毛虫病委员会(ICT),执行委员、副主席;

2011.08.6:   13届国际旋毛虫病大会,大会主席;  

2004-2019:   11121415届国际旋毛虫病大会,分委会主席;

2010-至今:   中国畜牧兽医学会兽医食品卫生学分会,副理事长。

2010-至今:吉林省人兽共患病学会秘书长、法人代表。

 

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